Endocrine Abstracts

Introduction: Metabolic surgery is the most effective long-term treatment for obesity. However, studies reveal that up to 40% of post-bariatric subjects experience long-term weight regain (WR), particularly those who discontinue surgical and nutritional follow-ups. In contrast, the ketogenic diet emerges as a pivotal therapy for obesity, showing convincing evidence in weight loss and improvement of weight-related complications.Purpose: This study aims to...

Background: Oxytocin (OXT) enhances glucose uptake and lipid utilization in adipose tissue and skeletal muscle.Dysfunction of the OXT system could underlie the pathogenesis of weight gain. Men and women with obesity were reported to have higher OXT blood levels compared to normal weight subjects. In contrast, metabolic syndrome has been associated with reduced fasting serum oxytocin in larger scale mixed gender studies.Aim: Data regarding the oxytocin sy...

Introduction: Obesity is a chronic neurometabolic disorder with complex psychological aspects. Patients with obesity often suffer from eating disorders and altered body image perception and show increased plasma concentrations of oxytocin (OT).Objective and Design: This pilot study investigates the interplay between psychological factors, OT levels, and very-low-calorie ketogenic diet (VLCKD)-induced weight loss. We collected data from patients with over...

Introduction: Metabolically associated fatty liver disease (MAFLD), prevalent in the Western world and a leading cause of liver transplantation among U.S. women, ranges from intra-hepatocyte lipid accumulation to cirrhosis. Fibrosis severity is crucial for prognosis, correlating with risks of advanced cirrhosis, portal hypertension, and hepatocellular carcinoma. 5-10% weight loss is associated with improvement of liver steatosis, but achieving >10% weight loss is usually n...